Qurazit 250 Capsules

COMPOSITION:

EACH CAPSULE CONTAINS:

PRESENTATION:

Quarzit 250 Capsule: 6 capsules packed in a blister and such 1 blister packed in a unit carton with insert .

INDICATIONS:

Qurazit 250 Capsule is indicated for the treatment of Upper respiratory tract infections: Pharyngitis, tonsillitis, acute bacterial sinusitis and acute otitis media; Lower respiratory tract infections: Community acquired pneumonia, bronchitis, acute bacterial exacerbation of chronic obstructive pulmonary diseases; Uncomplicated skin and soft tissue infections erythema migrans (the first stage of Lyme disease), erysipelas, impetigo and secondary pyoderma; Sexually transmitted diseases: Non gonococcal & gonococcal urethritis and cervicitis, genital ulcer diseases (chancroid); Gastric and duodenal infections caused by Helicobacter pylori.

DESCRIPTION:

Qurazit 250 Capsules contain Azithromycin, a macrolide antibiotic, which belongs to the azalide group. The mechanism of action of Azithromycin is based upon the suppression of bacterial protein synthesis by binding to the ribosomal 50S sub-unit and thus inhibiting the translocation of peptides.

AZITHROMYCIN IS ACTIVE AGAINST A BROAD RANGE OF GRAM POSITIVE AND GRAM NEGATIVE BACTERIA:

GRAM-POSITIVE COCCUS: Streptococcus pneumoniae, Streptococcus pyogenes (β- haemolytic Streptococcus group A), Staphylococcus aureus and Staphylococcus epidermidis. GRAM-POSITIVE BACILLUS: Clostridium perfringens (Erythromycin); Corynebacterium diptheriae; Listeria monocytogenes; Bacillus anthracis, Propionibacterium acnes and Nocardia spp. (certain strains).

GRAM-NEGATIVE MICROORGANISMS: Legionella pneumophila, Campylobacter jejuni and Bordetella pertussis, Haemophilus influenzae (Erythromycin and Clarithromycin), Haemophilus ducrei, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella multocida, Borrelia spp., some strains of Brucella spp. And Flavobacterium spp.

Most strains of Escherichia coli, species of Salmonella spp. (S. enterica), Shigella spp. and Aeromonas spp. And Bacteroides fragilis.

MYCOPLASMA: Mycoplasma pneumoniae hominis, Ureaplasma urealyticum, chlamydia trachomatis and C. pneumoniae spirochetes (Treponema pallidum).

GRAM-NEGATIVE ANAEROBES: Some strains of Actinomyces spp. Mycobacterium scrofulaceum and M. kansasii.

Most resistant to Erythromycin strains of Staphylococcus, Enterococcus and Streptococcus strains of S. aureus, methicillin-resistant and resistant to Azithromycin. Pseudomonas aeruginosa, some species Klebsiella spp., Enterobacter spp., Citrobacter spp., Proteus spp., Providencia spp., Morganella spp., Serracia spp. resistant to Azithromycin.

Azithromycin, orally administered is absorbed rapidly and widely distributed throughout the body. Peak plasma drug concentration of approximately 0.4µg/ml is achieved in 2 to 3 hours. Rapid distribution of Azithromycin into tissues and high concentration within cells result in significantly higher concentrations in tissues than in plasma or serum. Small amounts are metabolized in the liver by demethylation, the metabolites being excreted in the bile. Biliary excretion of Azithromycin, predominantly as unchanged drug, is a major route of elimination. A small amount of the drug is excreted unchanged in the urine (12% of the dose). The terminal elimination half-life is about 68 hours.

CONTRAINDICATIONS:

Qurazit 250 Capsules are contra-indicated in patients with a known hypersensitivity to Azithromycin or any of the macrolide or ketolide antibiotics or to any excipients.

SIDE EFFECTS:

Diarrhea, nausea, abdominal pain, loose stool, cramping, vaginitis, dyspepsia, vomiting, malaise, anorexia, pruritus, rash.

PRECAUTIONS:

Qurazit 250 Capsule must be taken at least one hour before or two hours after a meal. Concurrent administration of Aluminium and Magnesium containing Antacids and Azithromycin is not recommended. Azithromycin is eliminated via liver; therefore, caution should be taken when Azithromycin is administered to patients with impaired hepatic function.

DOSAGE:

ADULTS:

STORAGE:

Store in a dark and dry place below 25°C/ 30°C. Keep out of reach of children.